Efficacy of Rabeprazole in Gastric acid-Induced Disorders

Rabifine 20 (Rabeprazole sodium)

Efficacy of rabeprazole in gastric acid-induced disorders

Pharmacodynamic data of rabeprazole (a proton pump inhibitor) demonstrated that it can achieve an optimal acid suppression since the first dose and is able to maintain this advantage in the following days of therapy. Furthermore, rabeprazole has the highest pKa (~ 5.0, the pH at which a drug becomes 50% protonated) and for this reason the molecule can be activated at higher pH levels much faster than other PPIs.